Phototherapy as a Drug Concept
Phototherapy (PT) is commonly used to treat neonatal jaundice but there is substantial variation in the application of PT and the measured irradiance. Maisels, M J, J F Watchko, V K Bhutani, and D K Stevenson. “An Approach to the Management of Hyperb … More informationilirubinemia in the Preterm Infant Less than 35 Weeks of Gestation.” Journal Of Perinatology 32 (June 7, 2012): 660. To improve outcome a pharmacological perspective on the topic of phototherapy to use photons as a drug when prescribing PT was introduced. Lamola, Angelo A. “A Pharmacologic View of Phototherapy.” Clinics in Perinatology 43, no. 2 (June 2016): 259–76. doi: 10.1016/j.clp.2016.01.004. The idea is to apply the same therapeutic rigour to the use of phototherapy as one does to the use of a pharmacologic agent in the newborn. Maisels, M J, J F Watchko, V K Bhutani, and D K Stevenson. “An Approach to the Management of Hyperbilirubinemia in the Preterm Infant Less than 35 Weeks of Gestation.” Journal Of Perinatology 32 (June 7, 2012): 660 To do so it is crucial to measure the irradiance with a matching radiometer in the narrow most effective spectrum of 460-490nm in the correct way. Lamola, Angelo A. “A Pharmacologic View of Phototherapy.” Clinics in Perinatology 43, no. 2 (June 2016): 259–76. doi: 10.1016/j.clp.2016.01.004. , Kemper, Alex R, Thomas B Newman, Jonathan L Slaughter, M Jeffrey Maisels, Jon F Watchko, Stephen M Downs, Randall W Grout, et al. “Clinical Practice Guideline Revision: Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation” 150, no. 3 (2022). https://publications.aap.org/pediatrics/article/150/3/e2022058859/188726/ Clinical-Practice-Guideline-Revision-Management-of.