Weaning Strategies in the ICU for Ventilated Patients
—By Winnie Sywulak, BS, RRT-NPS
While mechanical ventilation is a life-saving modality, when it is prolonged there is a greater risk for patient complications, increased hospitalizations, and a longer length of hospital and intensive care unit (ICU) stay.i,ii Furthermore, research shows that patients on long-term mechanical ventilation can suffer post-traumatic stress disorder (PTSD) and other mental health issues.iii
In Dräger’s May 5, 2022, webinar, “Weaning Strategies in the ICU for Ventilated Patients,” Karsten J. Roberts, MSc, RRT, RRT-ACCS, RRT-NPS, FAARC, Director of Clinical Education, BS in Respiratory Therapy at Thomas Jefferson University, explored the critical role of respiratory therapists (RT) in decreasing the duration of mechanical ventilation through proven weaning practices.
“This is a topic that I feel very passionate about and one I think we as respiratory therapists should take ownership,” said Roberts. “When we start having conversations about value-added respiratory therapy, this is where we come into play, and this is where we really show our abilities as therapists to assess and make recommendations.”
RT/nursing collaboration
Roberts described the “Wake up and breathe protocol,” developed by Vanderbilt University Medical Center (VUMC).iv He explained how nurses and respiratory therapists collaborate during the weaning process, describing it step-by-step, including spontaneous awakening trials (SAT), sedation weaning, spontaneous breathing trials (SBT), and extubation with the ultimate goal of liberation from mechanical ventilation.
He presented data showing how the combination of SAT and SBT resulted in 3.1 fewer days on mechanical ventilation, reduced necessity of tracheostomy and lower risk for delirium.v
“We as respiratory therapists are working together in concert with our nursing colleagues to wean sedation and to get the patient off the ventilator as soon as possible. This profoundly decreases the risk of mortality and trauma that patients may experience from prolonged mechanical ventilation,” said Roberts.
Clinical guidelines and recommendations
Roberts provided a high-level overview of weaning guidelines from the American Thoracic Society (ATS) and American College of Chest Physicians (ACCP), along with clinical studies that support various weaning recommendations. He offered data - some in support, some against - various weaning strategies, including:
- SBTs conducted with/without inspiratory pressure augmentation
- Acute patient protocols to minimize sedation
- Extubation to preventative non-invasive ventilation (NIV)
- Early mobilization of acute patients ventilated for 24+ hours
- Mechanical ventilation liberation protocols
- Cuff leak tests for those with high extubation risks
- Administration of systemic steroids following extubation
- Vasopressor use during extubation and after discontinuation of mechanical ventilation
- Rapid shallow breathing index (RSBI) to gauge extubation success
- NIV versus high flow oxygen therapy use post extubation
- Standard RT assessment tool versus automated monitoring alert
Roberts urged RTs to use their own expertise and knowledge in accordance with the guidelines. He posed the example of assessing patients for liberation of mechanical ventilation, where standard criteria for a SBT readiness include oxygen saturation, positive end-expiratory pressure (PEEP) and fraction of inspired oxygen (FIO2), stating:
“I’ve seen documented in charts that the patient was not ready for a SBT because they were on 50% of oxygen concentration and on a PEEP of 7.5. So, what’s the problem? The guidelines we use in my institution say, “less than or equal to,” which means it can be equal to 50% and PEEP can be 7.5. Even in your morbidly obese patients you may see PEEP a little higher than that and the patient is still eligible for SBT. We shouldn’t let these things limit us too much in terms of when patients are ready for SBT.”
The individual patient
While Roberts stressed the importance of clinical guidelines in helping RTs take the best course of action when weaning patients off mechanical ventilation, he also acknowledged how every patient is different. He described how the process of weaning can differ widely from patient to patient based on their condition:
“In my opinion, we are seeing a more individualized approach to our mechanically ventilated patients. Not every patient is the same and not every time we liberate a patient from mechanical ventilation should it be the same.”
To view the recorded webinar and earn one contact hour Continuing Respiratory Care Education (CRCE) credit from the American Association for Respiratory Care, 9425 N. MacArthur Blvd., Suite 100, Irving, TX 75063 visit A Breath Ahead.
How Dräger can help
Dräger helps support ATS and ACCP ventilator liberation guidelines through technology and cost-efficiencies. To learn more, download our white paper.

How To Succeed With ATS And ACCP Ventilator Liberation Guidelines
New guidelines from the American Thoracic Society and American College of Chest Physicians provide valuable guidance for clinicians who manage patients who are on mechanical ventilation.
About the Author
Winnie Sywulak, BS, RRT-NPS, serves as Senior Marketing Manager for Respiratory Care Solutions for Dräger in North America, an international leader in the fields of medical and safety technology.
References
—i Haribhai S, Mahboobi SK. Ventilator Complications. [Updated 2022 Sep 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560535/, https://www.ncbi.nlm.nih.gov/books/NBK560535/
ii Overview: Getting Patients Off the Ventilator Faster: Facilitator Guide, AHRQ Safety Program for Mechanically Ventilated Patients, https://www.ahrq.gov/hai/tools/mvp/modules/vae/overview-off-ventilator-fac-guide.html#:~:text=Some%20long-term%20complications%20from%20mechanical%20ventilation%20include%20slower,anxiety%20disorders%2C%20chronic%20depression%2C%20and%20post-traumatic%20stress%20disorder
iii Girard, T.D., Shintani, A.K., Jackson, J.C. et al. Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study. Crit Care 11, R28 (2007). https://doi.org/10.1186/cc5708
iv ‘Wake Up and Breathe’ Strategy Allows Patients to Come Off Ventilator Sooner, Vanderbilt University Medical Center, May 17, 2007, https://www.newswise.com/articles/wake-up-and-breathe-strategy-allows-patients-to-come-off-ventilator-sooner1#:~:text=Newswise%20—%20A%20Vanderbilt%20study%20of%20intensive%20care,discharged%20from%20the%20ICU%20and%20hospital%20more%20quickly.
v Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, Taichman DB, Dunn JG, Pohlman AS, Kinniry PA, Jackson JC, Canonico AE, Light RW, Shintani AK, Thompson JL, Gordon SM, Hall JB, Dittus RS, Bernard GR, Ely EW. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet. 2008 Jan 12;371(9607):126-34. doi: 10.1016/S0140-6736(08)60105-1. PMID: 18191684.