Summary
Neonatal ventilation is an important part of the care delivered in the neonatal intensive care unit (NICU). But ventilation of preemies and neonates is a substantial challenge for even the most experienced caregiver: Respiratory insufficiency remains one of the major causes of neonatal mortality. Despite the introduction of sophisticated conventional ventilation, there are still some neonates who cannot be adequately ventilated.
Immature lungs and underdeveloped breathing require extremely gentle ventilation and advanced technology. The aim of any ventilation strategy is therefore to support the premature infant’s respiratory system without inducing damage to the lung or the brain. Our ventilation strategies accompany neonates and care givers from the beginning to the end of respiratory challenges: It is our aim to help you prevent or minimise pulmonary injury, impairment and work of breathing, whilst optimising comfort and allowing your little patients to grow safely.
Improve your outcome with volume guarantee
—Volume guarantee is a mode of ventilation used for measuring tidal volumes and monitoring changes in lung characteristics with sophisticated software algorithms. It has been designed to combine the advantages of both pressure-limited ventilation and volume-controlled ventilation. Clinical evidence has shown that babies ventilated with volume guarantee are more likely to survive – free of lung damage and chronic diseases. These benefits can also attribute to cost reductions in the NICU.

Downloads to enrich your knowledge

Volume Guarantee for Neonates
Read more about new approaches in volume targeted ventilation for newborn babies.

Prof. Martin Keszler on Neonatal Ventilation
Prof. Martin Keszler talks about how neonatal ventilation has progressed throughout the years and how volume guarantee can support a positive outcome of neonatal ventilation.

Case study: Volume Guarantee in Seattle
In this case study, you will read about the initiation and ongoing clinical management of infants supported by volume guarantee.

Ventilation Insights: Volume Guarantee Ventilation
The aim of any ventilation strategy is to support the neonate‘s respiratory system without inducing damage to the lung or the brain. Volume Guarantee ventilation supports stabilisation of the infant and gentle respiratory treatment with a more stable minute ventilation. Learn more in our Ventilation Insights on how Volume Guarantee ventilation helps to improve patient outcome.

Literature list: Volume Guarantee
Want to read more about clinical studies, cases and reviews on volume guarantee? Take a look at our literature list.
High-Frequency Oscillatory Ventilation (HFOV) for Neonates
—HFOV is a mode of ventilation which has been in clinical use for over thirty years. In many hospitals around the world, HFOV is now an established first-intention ventilation approach for respiratory disease. HFOV is used to treat diseases such as respiratory distress syndrome, pneumonia, meconium aspiration syndrome, persistent pulmonary hypertension of the newborn and lung hypoplasia – more successfully and more gently than conventional ventilation.
Recommended downloads

Theoretical and practical applications of HFOV
The booklet 'High-Frequency Oscillatory Ventilation' written by Prof. Jane Pillow aims both to help less experienced clinicians become familiar with high-frequency oscillation, whilst also providing additional detail to enhance the understanding of more experienced HFOV users.

Ventilation Insights: High-Frequency Oscillation
High-Frequency Oscillatory Ventilation (HFOV) is a comprehensive ventilator strategy applied as priori and rescue ventilator modality in order to improve pulmonary gas exchange. It offers opportunities for lung protective ventilation whilst minimising rheotrauma. Learn more in our Ventilation Insights on how HFOV helps to improve patient outcome.
Mandatory Minute Ventilation (MMV)
—Mandatory Minute Ventilation (MMV) is a relatively simple closed-loop mode of ventilation, whereby the ventilator delivers pressure-limited, volume-targeted mandatory breaths when the minute volume (generated by pressure supported spontaneous breaths) falls below a target minimum Minute Volume (MV). It gives you the possibility to control your patient’s ventilation, whilst safeguarding on a minimum minute ventilation level. In addition, it can be considered a safe weaning strategy as it combines frequency adaptation and pressure adaptation in one mode and adapts to the individual patient needs. Furthermore, it adapts safely for leakage for trigger sensitivity and compensates for leakage in volume guarantee.

Webinar: Mandatory Minute Ventilation with Prof. Jane Pillow
Our webinar “Mandatory Minute Ventilation” will help you become more familiar with the theory, clinical application and operating principle of MMV.
- Understanding how MMV works
- Theoretical benefits and risks of MMV
- Clinical application of MMV in neonates
- PC-MMV and Volume Guarantee operating principle
Recommended downloads

Ventilation Insights: MMV in Premature Infants
The start of ventilation therapy is always the start of a weaning process. To prevent chronic lung diseases such as BPD, it is essential to directly help the infant to regain their own respiratory drive. Mandatory Minute Ventilation 'closes the loop' in the weaning process. Learn more in our Ventilation Insights on how Mandatory Minute Ventilation helps to improve patient outcome.
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Dräger Babylog® VN800

Neonatal Ventilation Accessories
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